A new study has uncovered a surprising vulnerability in prostate cancer’s survival system — and scientists believe it could change how we treat the disease. The Enzymes That Shield Cancer Prostate cancer cells rely on two enzymes, PDIA1 and PDIA5 , to protect their most critical driver: the androgen receptor (AR). This receptor fuels tumour growth, helping cancer cells survive even during treatment. Researchers found that PDIA1 and PDIA5 act like molecular bodyguards — keepi

A 2025 Nature Biotechnology paper by researchers from the Arc Institute, Gladstone Institutes, and UCSF has introduced a revolutionary way to reprogram human T cells without altering their DNA sequence. The team developed an all-RNA epigenetic editing platform that uses molecular “switches” called CRISPRoff and CRISPRon to silence or activate genes by rewriting their epigenetic code, specifically, DNA methylation marks. Unlike traditional CRISPR, which cuts DNA, this syst

Depression is increasingly recognized as a neurobiological disorder rooted in molecular and synaptic dysfunction rather than a purely psychological condition. Contemporary research links major depressive disorder (MDD) to disrupted serotonergic signaling, oxidative stress, and impaired synaptic plasticity (Correia et al., 2023; Shu et al., 2025). To investigate these molecular dynamics, model organisms such as Aplysia californica have proven invaluable due to their accessibl

Recent advances in cellular engineering are rewriting the future of medicine. Imagine a world where human cells are programmed to sense...

If you’ve followed the decades-long journey to an HIV vaccine, you know it’s been full of challenges: mutations, elusive immune...

overview of its genome The increasing prevalence of multidrug-resistant bacteria, particularly those harboring the New Delhi...

Exploring the unseen world! 🔬✨ Check out our latest microscopy session as we dive deep into the tiny wonders of nature. From plant cells...

As technology advances and innovation flourishes, the world faces a growing challenge—climate change. Every modern convenience, from...

During summer school at Columbia University, I had the exciting opportunity to conduct an experiment involving bacterial transformation-...

In my recent fieldwork, I had the privilege of visiting over 20 Anganwadis across Mumbai, immersing myself in the vibrant world of early...

Ever wondered how athletes push through the toughest challenges without giving up? Discover the secrets of stamina

learning how to measure and record blood pressure using machines When I volunteered at the APLA Dawakhana clinics in Dharavi (August -...